RM191A:
RM191A (BioCuplex™) is a breakthrough topical treatment for neuropathic pain, inflammation, and UV damage.
Our small molecule complex works at the first signs of inflammation and oxidative stress, protecting DNA, promoting cellular repair, and modulating pain.
It boosts the reparative processes and outperforms the body’s natural antioxidant and reparative systems by around 20x.
RM191A is formulated into topical applications. It is patented, safe, effective and shelf stable.
Read our peer-reviewed paper on RM191A, published in Redox Biology, Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic, Jan 2021.
RM191A is safe, non-toxic,
non-teratogentic & readily bioavailable in
in vivo models and human clinical trials.
Analgesic
RM191A is in clinical-stage testing as a topical drug to treat chronic, severe, refractory neuropathic pain. The phase 2 clinical trial was conducted at the Pain Management Research Centre at Royal North Shore Hospital, Sydney Australia (CT Ref No: HREC/16/HAWKE/483; ACTRN12617000206325). The results of the trial will be published soon.
Anti-inflammatory
Chronic inflammation drives a multitude of disease conditions. Topical application of RM191A reduces inflammation by 75%. It inhibits activation of the inflammatory cascade, down-regulates pro-inflammatory signalling pathways and inflammatory cytokines, suppresses ROS/RNS, and beneficially modulates immune cell activation.
Protects against
UV damage
Ultraviolet radiation causes damage to skin cells and DNA. RM191A has been shown not only to protect the DNA in the dermis and epidermis during UV exposure, but also enhance skin repair following UV exposure.
Reduces
oxidative damage
RM191A is a unique SOD mimetic, neutralising radical oxygen and nitrogen species (ROS & RNS) in the body. These free radicals cause damage to cellular function and trigger inflammatory, overactive immune responses and pain. SOD is part of the body's innate system for dealing with free radicals and the damage they cause. RM191A outperforms innate SOD by around 20x.
Accelerates
wound healing
RM191A accelerates wound healing and skin regeneration. In skin-injury tests, RM191A gel reduced wound healing time by 50%, cutting healing time from 23 days to 10-12 days. It also improves collagen formation following injury by more than 100x.
Geroprotective
Skin damage is a major factor in the ageing process, occurring via several processes. RM191A has been shown to reduce age-associated oxidative stress in skin, improve collagen production by more than 100x, and reduce age-related immune cell (mast cell) infiltration by 70%.